Direct Correlation between Diffusion of Loxosceles reclusa Venom and Extent of Dermal Inflammation

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Direct correlation between diffusion of Loxosceles reclusa venom and extent of dermal inflammation.

OBJECTIVES Envenomation by Loxosceles species (brown recluse) spiders results in large dermal inflammatory lesions. Venom-induced dermal inflammation occurs indirectly via soluble mediators of inflammation. This study aimed to explore whether the anatomic extent of dermonecrotic arachnidism is due to the cascade of soluble proinflammatory mediators elicited by venom deposited at the bite site, ...

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Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).

Envenomation by the brown recluse spider (Loxosceles reclusa) may cause local dermonecrosis and, rarely, coagulopathies, kidney failure and death. A venom phospholipase, SMaseD (sphingomyelinase D), is responsible for the pathological manifestations of envenomation. Recently, the recombinant SMaseD from Loxosceles laeta was demonstrated to hydrolyse LPC (lysophosphatidylcholine) to produce LPA ...

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Influence of spider silk on refugia preferences of the recluse spiders Loxosceles reclusa and Loxosceles laeta (Araneae: Sicariidae).

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Refugia preferences by the spiders Loxosceles reclusa and Loxosceles laeta (Araneae: Sicariidae).

A variety of refugia were offered to different instars of brown recluse spiders, Loxosceles reclusa Gertsch and Mulaik, and a South American recluse spider, L. laeta (Nicolet), to determine whether they preferred certain types of refugia spaces. Variables included (1) crevice widths ranging from 3.2 to 21 mm, (2) horizontal and vertical orientations, and (3) new refugia or refugia that had silk...

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ژورنال

عنوان ژورنال: Academic Emergency Medicine

سال: 2001

ISSN: 1069-6563,1553-2712

DOI: 10.1111/j.1553-2712.2001.tb02107.x